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BD 1047 dihydrobromide
Axon 1215
- Parent CAS: 138356-20-4
Purity:
99%
- Soluble in water
- MF: C13H20Cl2N2.HBr
- MW: 437.04
Description
BD 1047 dihydrobromide is a selective sigma-1 receptor antagonist used to block sigma-1 receptor-mediated modulation of cellular stress and neurotransmission pathways.
Sigma-1 receptors are ligand-regulated chaperone proteins involved in endoplasmic reticulum-mitochondrial signaling, calcium homeostasis, pain processing and neuroprotection. BD 1047 is a useful antagonist for dissecting sigma-1 receptor function.
Key Features
- Selective sigma-1 receptor antagonist
- Blocks sigma-1 receptor-mediated cellular responses
- Useful in pain, stress and neuroprotection pathway studies
- Supports investigation of ER-mitochondrial signaling
Applications
- Sigma-1 receptor pharmacology
- Pain and nociception research
- ER stress and calcium signaling studies
- Neuroprotection and CNS pathway models
More Information
| Parent CAS No. | 138356-20-4 |
|---|---|
| Chemical Name | N-[2-(3,4-Dichloro-phenyl)-ethyl]-N,N',N'-trimethyl-ethane-1,2-diamine dihydrobromide |
| SMILES | C1(Cl)C=C(CCN(C)CCN(C)C)C=CC=1Cl.Br.Br |
| MFCD | MFCD00792739 |
| InChi | InChI=1S/C13H20Cl2N2.2BrH/c1-16(2)8-9-17(3)7-6-11-4-5-12(14)13(15)10-11;;/h4-5,10H,6-9H2,1-3H3;2*1H |
| InChiKey | WOALTFHGLDVJHK-UHFFFAOYSA-N |
| CID | 45073418 |
| Short Description | Sigma-1 antagonist |
BD 1047 dihydrobromide
sigma-1 receptor antagonist
BD1047
BD-1047
Sigma-1
sigma-1 receptor
Antagonist
calcium signaling
endoplasmic reticulum stress
Sigma-1 receptor pharmacology
Pain and nociception research
ER stress and calcium signaling studies
Neuroprotection and CNS pathway models
mitochondrial function
pain research
GPCR pharmacology
receptor selectivity
signal transduction
CNS
CAS 138356-20-4
CAS 138356-21-5
Axon Medchem
Axon 1215
Supplier
Vendor
References
- G Skuza and Z Rogóz. Effect of BD 1047, a sigma1 receptor antagonist, in the animal models predictive of antipsychotic activity. Pharmacol Rep. 2006, 58(5), 626-35.
- N. Egashira et al. Involvement of the sigma1 receptor in inhibiting activity of fluvoxamine on marble-burying behavior: Comparison with paroxetine. Eur. J. Pharmacol. 2007, 563(1-3), 149-154.
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