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PNU 282987 hydrochloride
- Parent CAS: 711085-63-1
- Optical Purity: Optically pure
- Soluble in water and DMSO
- MF: C14H17ClN2O.HCl
- MW: 301.21
Description
PNU 282987 hydrochloride is an α7 nicotinic acetylcholine receptor (nAChR) agonist with Ki (α7 nAChR) and EC50 (α7-5HT3 chimera) values of 27 nm and 154 nM, respectively. PNU 282987 hydrochloride was also shown to open native α7 nAChRs in cultured rat neurons and to reverse an amphetamine-induced gating deficit in rats.
More Information
| Parent CAS No. | 711085-63-1 |
|---|---|
| Chemical Name | (R)-4-Chloro-N-(quinuclidin-3-yl)benzamide hydrochloride |
| SMILES | C1C=C(C(=O)N[C@H]2CN3CCC2CC3)C=CC=1Cl.Cl |&1:6,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C14H17ClN2O.ClH/c15-12-3-1-11(2-4-12)14(18)16-13-9-17-7-5-10(13)6-8-17;/h1-4,10,13H,5-9H2,(H,16,18);1H/t13-;/m0./s1 |
| InChiKey | HSEQUIRZHDYOIX-ZOWNYOTGSA-N |
| CID | 11243536 |
| Short Description | nAChR agonist |
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