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Dolutegravir
- GSK 1349572 - Soltegravir - Tivicay
- Soluble in DMSO
- MF: C20H19F2N3O5
- MW: 419.38
Description
Dolutegravir is an HIV integrase inhibitor with potent in vitro anti-HIV activity (IC50 value of 0.51 nM), an in vitro resistance profile different from those of other integrase inhibitors, and favorable preclinical safety and pharmacokinetics.
More Information
| Parent CAS No. | 1051375-16-6 |
|---|---|
| Chemical Name | (4R,12aS)-N-(2,4-Difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxamide |
| MFCD | N.A. |
| Short Description | HIV integrase inhibitor |
References
- S Min et al. Pharmacokinetics and safety of S/GSK1349572, a next-generation HIV integrase inhibitor, in healthy volunteers. Antimicrob Agents Chemother. 2010 Jan;54(1):254-8.
- S Hare et al. Structural and functional analyses of the second-generation integrase strand transfer inhibitor dolutegravir (S/GSK1349572). Mol Pharmacol. 2011 Oct;80(4):565-72.
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