Inhibitor of 15-lipoxygenase-1 (15-LOX-1) with both anti-inflammatory and neuroprotective properties (IC50 value of 12 µM). Ex vivo biological evaluation in precision-cut lung slices (PCLS) showed inhibition of pro-inflammatory gene expression and in vitro studies on neuronal HT-22 cells showed a strong protection against glutamate toxicity for this 15-LOX-1 inhibitor.
*Sold in collaboration with RuG (University of Groningen)

KEYWORDS: Thiolox | supplier | Lipoxygenase inhibitor | CAS [1202193-89-2] | Fatty acid (Arachidonic acid) | LOX | Inhibitor | Enzymes