C-DIM8 - DIM-C-pPhOH

Based on 21 reference(s) in Google Scholar 8 10 21

Axon 2827

CAS [151358-47-3]

MF C23H18N2O
MW 338.40

Purity: 98%
Soluble in DMSO

C-DIM8

Description

C-DIM8 is a Nur77 (NR4A1) antagonist. Treatment of pancreatic and colon cancer cells with C-DIM8 mimics the effects of NR4A1 knockdown and decreases β1-integrin expression, β1-integrin regulated genes and responses including migration and adhesion.

S Chintharlapalli et al. Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways. J Biol Chem. 2005 Jul 1;280(26):24903-14.

E Hedrick et al. The nuclear orphan receptor NR4A1 regulates β1-integrin expression in pancreatic and colon cancer cells and can be targeted by NR4A1 antagonists. Mol Carcinog. 2017 Sep;56(9):2066-2075.

Nur77 antagonist

Chemical name

4-(Di(1H-indol-3-yl)methyl)phenol

Parent CAS No.

[151358-47-3]

Order

Size	Unit Price	Stock
10 mg	€95.00	In Stock
50 mg	€345.00	In Stock

Special Offers

Size	Unit Price	Stock
2 x 10 mg	€80.00	In Stock

Need more? Bulk Inquiry

Related Products

Axon ID	Name	Description	From price
2575	C-DIM12	Nurr1 activator that stimulates apoptosis in bladder cancer cells		€85.00
2828	C-DIM5	Nur77 agonist		€95.00

Customer Support

Customer Services

About Axon Medchem

Contact Us

C-DIM8 - DIM-C-pPhOH

Description

Chemical name

Parent CAS No.

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Customer Support

Customer Services

About Axon Medchem

Contact Us

C-DIM8 - DIM-C-pPhOH

Description

Chemical name

Parent CAS No.

Related Products

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Send us a message

Contact Us