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C-DIM8
- DIM-C-pPhOH
Axon 2827
CAS:
151358-47-3
Purity:
98%
- Soluble in DMSO
- MF: C23H18N2O
- MW: 338.4
Description
C-DIM8 is a Nur77 (NR4A1) antagonist. Treatment of pancreatic and colon cancer cells with C-DIM8 mimics the effects of NR4A1 knockdown and decreases β1-integrin expression, β1-integrin regulated genes and responses including migration and adhesion.
More Information
| Parent CAS No. | 151358-47-3 |
|---|---|
| Chemical Name | 4-(Di(1H-indol-3-yl)methyl)phenol |
| SMILES | C1C(O)=CC=C(C(C2C3C=CC=CC=3NC=2)C2=CNC3C=CC=CC2=3)C=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C23H18N2O/c26-16-11-9-15(10-12-16)23(19-13-24-21-7-3-1-5-17(19)21)20-14-25-22-8-4-2-6-18(20)22/h1-14,23-26H |
| InChiKey | QCPDFNWJBQMXLI-UHFFFAOYSA-N |
| CID | 2940609 |
| Short Description | Nur77 antagonist |
References
- S Chintharlapalli et al. Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways. J Biol Chem. 2005 Jul 1;280(26):24903-14.
- E Hedrick et al. The nuclear orphan receptor NR4A1 regulates β1-integrin expression in pancreatic and colon cancer cells and can be targeted by NR4A1 antagonists. Mol Carcinog. 2017 Sep;56(9):2066-2075.
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