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C-DIM12
- DIM-C-pPhCl
Axon 2575
CAS:
178946-89-9
Purity:
99%
- Soluble in DMSO
- MF: C23H17ClN2
- MW: 356.85
Description
Potent and specific Nurr1 activator that stimulates Nurr1 mediated apoptosis axis in bladder cancer cells and tumors and inhibits NF-κB–dependent gene expression in glial cells by stabilizing nuclear corepressor proteins, which reduces binding of p65 to inflammatory gene promoters. C-DIM12 protects against loss of dopamine neurons in the substantia nigra as well as dopamine terminals in the striatum in MPTP-induced mouse models for Parkinson's disease.
More Information
| Parent CAS No. | 178946-89-9 |
|---|---|
| Chemical Name | 3,3'-((4-chlorophenyl)methylene)bis(1H-indole) |
| SMILES | C(C1C2=C(NC=1)C=CC=C2)(C1C2=C(NC=1)C=CC=C2)C1=CC=C(Cl)C=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C23H17ClN2/c24-16-11-9-15(10-12-16)23(19-13-25-21-7-3-1-5-17(19)21)20-14-26-22-8-4-2-6-18(20)22/h1-14,23,25-26H |
| InChiKey | LTLRXTDMXOFBDW-UHFFFAOYSA-N |
| CID | 5302583 |
| Short Description | Nurr1 activator |
References
- T. Inamoto et al.1,1-Bis(3'-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth. Mol Cancer Ther. 2008 Dec;7(12):3825-33.
- X Li et al. Structure-dependent activation of NR4A2 (Nurr1) by 1,1-bis(3'-indolyl)-1-(aromatic)methane analogs in pancreatic cancer cells. Biochem Pharmacol. 2012 May 15;83(10):1445-55.
- BR De Miranda et al. Neuroprotective efficacy and pharmacokinetic behavior of novel anti-inflammatory para-phenyl substituted diindolylmethanes in a mouse model of Parkinson's disease. J Pharmacol Exp Ther. 2013 Apr;345(1):125-38.
- BR De Miranda et al. The Nurr1 Activator 1,1-Bis(3'-Indolyl)-1-(p-Chlorophenyl)Methane Blocks Inflammatory Gene Expression in BV-2 Microglial Cells by Inhibiting Nuclear Factor κB. Mol Pharmacol. 2015 Jun;87(6):1021-34.
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