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C-DIM5
- DIM-C-pPhOCH3
- Soluble in DMSO
- MF: C24H20N2O
- MW: 352.43
Description
C-DIM5 is an agonist of the orphan nuclear receptor NR4A1 (Nur77) that activates pro-apoptotic NR4A1-dependent responses in selected cancer-cell models. Its effects include induction of the death ligand TRAIL and cell-cycle-regulatory genes.
C-DIM5 reduces tumor-cell survival, promotes apoptosis and induces p21-associated cell-cycle arrest in pancreatic cancer cells. It is useful for studying context-dependent NR4A1 agonism, nuclear-versus-mitochondrial Nur77 signaling and receptor-mediated apoptotic transcription.
Key Features
- NR4A1/Nur77 agonist
- Induces TRAIL expression
- Promotes apoptosis
- Induces p21-associated cell-cycle arrest
Applications
- NR4A1 agonist pharmacology
- TRAIL and apoptosis studies
- Cell-cycle regulation research
- Nur77 transcriptional signaling
- Pancreatic cancer models
More Information
| Parent CAS No. | 33985-68-1 |
|---|---|
| Chemical Name | 3,3'-((4-Methoxyphenyl)methylene)bis(1H-indole) |
| SMILES | C1C(OC)=CC=C(C(C2C3C=CC=CC=3NC=2)C2=CNC3C=CC=CC2=3)C=1 |
| MFCD | MFCD01217840 |
| InChi | InChI=1S/C24H20N2O/c1-27-17-12-10-16(11-13-17)24(20-14-25-22-8-4-2-6-18(20)22)21-15-26-23-9-5-3-7-19(21)23/h2-15,24-26H,1H3 |
| InChiKey | ZCCMKJAXOIFTHH-UHFFFAOYSA-N |
| CID | 11371604 |
| Short Description | Nur77 agonist |
References
- S Chintharlapalli et al. Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways. J Biol Chem. 2005 Jul 1;280(26):24903-14.
- SO Lee et al. p21 expression is induced by activation of nuclear nerve growth factor-induced Balpha (Nur77) in pancreatic cancer cells. Mol Cancer Res. 2009 Jul;7(7):1169-78.
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