Nurr

Nurr

NR4A family orphan nuclear receptors are an important class of transcription factors for development and homeostasis of dopaminergic neurons that also inhibit expression of inflammatory genes in glial cells. Nur77 (NGIF-B/NR4A1), Nurr1 (NOT/NR4A2), and NOR-1 (MINOR/NR4A3) form a family of orphan nuclear receptors with a highly conserved DNA-binding domain and COOH-terminal ligand-binding domain, but minimal homology in their NH2-terminal region. Nurr1 is an atypical member of the NR superfamily, which are primarily ligand-activated receptors, which regulate gene expression via recognition of specific DNA-binding sequences. Nurr1 is important for dopaminergic neuron function via regulation of tyrosine hydoxylase expression. Preliminary reports suggest a role for Nurr1 in rheumatoid arthritis and cancer through modulation of apoptosis.

Read More
sort-descending
  • C-DIM12
    2575
    C-DIM12
    The price depends on the options chosen on the product page

    From $93.50

  • C-DIM8
    2827
    C-DIM8
    The price depends on the options chosen on the product page

    From $104.50

  • C-DIM5
    2828
    C-DIM5
    The price depends on the options chosen on the product page

    From $104.50

  • 4A7C-301
    4081
    4A7C-301
    The price depends on the options chosen on the product page

    From $143.00

  • Nurr1 agonist 7
    4308
    Nurr1 agonist 7
    The price depends on the options chosen on the product page

    From $132.00

  • Nurr1 agonist 8
    4310
    Nurr1 agonist 8
    The price depends on the options chosen on the product page

    From $132.00

6 Items

More About Nurr

NR4A family orphan nuclear receptors are an important class of transcription factors for development and homeostasis of dopaminergic neurons that also inhibit expression of inflammatory genes in glial cells[1]. Nur77 (NGIF-B/NR4A1), Nurr1 (NOT/NR4A2), and NOR-1 (MINOR/NR4A3) form a family of orphan nuclear receptors with a highly conserved DNA-binding domain and COOH-terminal ligand-binding domain, but minimal homology in their NH2-terminal region. Nurr1 is an atypical member of the NR superfamily, which are primarily ligand-activated receptors, which regulate gene expression via recognition of specific DNA-binding sequences. Nurr1 is important for dopaminergic neuron function via regulation of tyrosine hydoxylase expression. Preliminary reports suggest a role for Nurr1 in rheumatoid arthritis and cancer through modulation of apoptosis[2].

[1] BR De Miranda et al. The Nurr1 Activator 1,1-Bis(3'-Indolyl)-1-(p-Chlorophenyl)Methane Blocks Inflammatory Gene Expression in BV-2 Microglial Cells by Inhibiting Nuclear Factor κB. Mol Pharmacol. 2015 Jun;87(6):1021-34.
[2] T. Inamoto et al.1,1-Bis(3'-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth. Mol Cancer Ther. 2008 Dec;7(12):3825-33.

Loading...