Bulk Inquiry
4A7C-301
- Soluble in 0.1N HCl(aq), DMSO and EtOH
- MF: C27H38ClN9
- MW: 524.1
Description
4A7C-301 is a brain-penetrant Nurr1 agonist with an EC50 value of 6.53 µM and exhibits robust neuroprotective effects in vitro. In addition, 4A7C-301 protects midbrain dopamine neurons in the MPTP-induced male mouse model of PD and improves both motor and non-motor olfactory deficits without dyskinesia-like behaviors. Furthermore, 4A7C-301 significantly ameliorates neuropathological abnormalities and improves motor and olfactory dysfunctions in AAV2-mediated α-synuclein-overexpressing male mouse models.
More Information
| Parent CAS No. | N.A. |
|---|---|
| Chemical Name | N1-(4,6-Bis(4-ethylpiperazin-1-yl)pyrimidin-2-yl)-N2-(7-chloroquinolin-4-yl)ethane-1,2-diamine |
| MFCD | N.A. |
| Short Description | Nurr1 agonist |
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 2575 | C-DIM12 |
From $93.50 |
| 2827 | C-DIM8 |
From $104.50 |
| 2828 | C-DIM5 |
From $104.50 |
| 4308 | Nurr1 agonist 7 |
From $132.00 |
| 4310 | Nurr1 agonist 8 |
From $132.00 |
