Bulk Inquiry
25CN-NBOH hydrochloride
- NBOH-2C-CN hydrochloride
- Parent CAS: 1391489-32-9
- Soluble in water and DMSO
- MF: C18H20N2O3.HCl
- MW: 348.82
Description
25CN-NBOH is a highly selective and brain penetrant 5-HT2A receptor agonist (Ki value of 1.3 nM; EC50 value of 2.1 nM). Moreover, 25CN-NBOH was behaviorally active in two mouse models of hallucinogenic effects.
More Information
| Parent CAS No. | 1391489-32-9 |
|---|---|
| Chemical Name | 4-(2-(2-Hydroxybenzylamino)ethyl)-2,5-dimethoxybenzonitrile hydrochloride |
| SMILES | C1C(OC)=C(CCNCC2C=CC=CC=2O)C=C(OC)C=1C#N.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C18H20N2O3.ClH/c1-22-17-10-15(11-19)18(23-2)9-13(17)7-8-20-12-14-5-3-4-6-16(14)21;/h3-6,9-10,20-21H,7-8,12H2,1-2H3;1H |
| InChiKey | JQVAEIIIMVMJBO-UHFFFAOYSA-N |
| CID | 90489019 |
| Short Description | 5-HT2A agonist |
References
- M Hansen et al. Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists. ACS Chem Neurosci. 2014 Mar 19;5(3):243-9.
- WE Fantegrossi et al. Hallucinogen-like effects of 2-([2-(4-cyano-2,5-dimethoxyphenyl) ethylamino]methyl)phenol (25CN-NBOH), a novel N-benzylphenethylamine with 100-fold selectivity for 5-HT₂A receptors, in mice. Psychopharmacology (Berl). 2015 Mar;232(6):1039-47.
- AA Jensen et al. Detailed Characterization of the In Vitro Pharmacological and Pharmacokinetic Properties of N-(2-Hydroxybenzyl)-2,5-Dimethoxy-4-Cyanophenylethylamine (25CN-NBOH), a Highly Selective and Brain-Penetrant 5-HT2A Receptor Agonist. J Pharmacol Exp Ther. 2017 Jun;361(3):441-453.
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