25CN-NBOH hydrochloride - NBOH-2C-CN hydrochloride

Based on 5 reference(s) in Google Scholar 8 10 5

Axon 2811

CAS [1539266-32-4]

MF C18H20N2O3.HCl
MW 348.82

Purity: 98%
Soluble in water and DMSO

25CN-NBOH hydrochloride

Description

25CN-NBOH is a highly selective and brain penetrant 5-HT2A receptor agonist (Ki value of 1.3 nM; EC50 value of 2.1 nM). Moreover, 25CN-NBOH was behaviorally active in two mouse models of hallucinogenic effects.

M Hansen et al. Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists. ACS Chem Neurosci. 2014 Mar 19;5(3):243-9.

WE Fantegrossi et al. Hallucinogen-like effects of 2-([2-(4-cyano-2,5-dimethoxyphenyl) ethylamino]methyl)phenol (25CN-NBOH), a novel N-benzylphenethylamine with 100-fold selectivity for 5-HT₂A receptors, in mice. Psychopharmacology (Berl). 2015 Mar;232(6):1039-47.

AA Jensen et al. Detailed Characterization of the In Vitro Pharmacological and Pharmacokinetic Properties of N-(2-Hydroxybenzyl)-2,5-Dimethoxy-4-Cyanophenylethylamine (25CN-NBOH), a Highly Selective and Brain-Penetrant 5-HT2A Receptor Agonist. J Pharmacol Exp Ther. 2017 Jun;361(3):441-453.

CNS 5-HT2A A17

Selective brain penetrant 5-HT2A receptor agonist

Chemical name

4-(2-(2-Hydroxybenzylamino)ethyl)-2,5-dimethoxybenzonitrile hydrochloride

Parent CAS No.

[1391489-32-9]

Order

Size	Unit Price	Stock
10 mg	€150.00	In Stock
50 mg	€560.00	In Stock

Special Offers

Size	Unit Price	Stock
2 x 10 mg	€260.00	In Stock

Need more? Bulk Inquiry

Related Products

Axon ID	Name	Description
1102	Nefazodone hydrochloride	Antidepressant; 5-HT2A antagonist	€85.00
1103	MDL 100151	5-HT2A antagonist	€110.00
1104	MDL 100907	5-HT2A antagonist	€110.00
1105	MDL 100009	5-HT2A antagonist	€125.00
1106	(±)-MDL 105725	5-HT2A antagonist	€210.00
1107	(+)-MDL 105725	5-HT2A antagonist	Inquire
1108	(-)-MDL 105725	5-HT2A antagonist	Inquire
1143	Aripiprazole	Atypical antipsychotic	€75.00
1144	Thio-aripiprazole	Atypical antipsychotic	€140.00
1146	Clozapine	Atypical antipsychotic	€50.00
1147	Isoclozapine	Typical antipsychotic	€135.00
1148	GMC 1-169	Atypical antipsychotic	€150.00
1149	GMC 61-39	Atypical antipsychotic	Inquire
1150	GMC 2-83	Atypical antipsychotic	€160.00
1152	GMC 1-165	Clozapine analog with 5-HT2A and M1 affinity, devoid of D1/D2 affinities	€140.00
1247	PNU 22394 hydrochloride	Potent 5-HT ligand with full agonistic properties for 5-HT2C	€90.00
1439	Eplivanserin	5-HT2A antagonist/inverse agonist	€80.00
1446	Ziprasidone hydrochloride	Atypical antipsychotic	€50.00
1450	Ketanserin	5-HT2A antagonist	€55.00
1493	Iloperidone	Atypical antipsychotic	€85.00
1499	Flibanserin	5-HT1A agonist and 5-HT2A antagonist	€95.00
1503	Asenapine maleate	Atypical antipsychotic	€70.00
2335	Brexpiprazole dihydrochloride	Drug candidate with high affinity for 5-HT1A, 5-HT2A, D2L, α1B, and α2C-adrenergic receptors	€135.00
2851	GMC 1-161	Clozapine analog with 5-HT2A, M1 and D2 affinity, devoid of D1 affinities	€135.00
3511	Cyproheptadine hydrochloride	5-HT2A and H1 antagonist	€50.00
3859	Roluperidone	Sigma-2 and 5-HT2A receptor antagonist	€120.00
3925	IHCH-7079	5-HT2A receptor arrestin-biased agonist	€150.00

Customer Support

Customer Services

About Axon Medchem

Contact Us

25CN-NBOH hydrochloride - NBOH-2C-CN hydrochloride

Description

Chemical name

Parent CAS No.

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Customer Support

Customer Services

About Axon Medchem

Contact Us

25CN-NBOH hydrochloride - NBOH-2C-CN hydrochloride

Description

Chemical name

Parent CAS No.

Related Products

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Send us a message

Contact Us