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Axon 2810
CAS [2097381-85-4]
MF C27H33N5O4SMW 523.65
VH298 is a potent and selective VHL inhibitor (Kd value of 80-90 nM) that stabilizes HIF-α and elicits a hypoxic response via the blockade of the VHL:HIF-α protein–protein interaction downstream of HIF-α hydroxylation by PHD enzymes.
KEYWORDS: VH298 | supplier | VHL inhibitor | VH-298 | VH 298 | CAS [2097381-85-4] | Smad | Ubiquitin Ligase (E3; VHL) | Inhibitor | Enzymes | von-Hippel-Lindau | prolyl hydroxylase | PHD
(2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
[2097381-85-4]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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