Clozapine N-oxide - CNO

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2796

CAS [34233-69-7]

MF C18H19ClN4O
MW 342.82

Purity: 99%
Soluble in water and DMSO

Clozapine N-oxide

Description

Metabolite of the atypical antipsychotic agent Clozapine (Axon 1146). Muscarinic DREADD (designer receptor exclusively activated by a designer drug) agonist.

V Nawaratne et al. New insights into the function of M4 muscarinic acetylcholine receptors gained using a novel allosteric modulator and a DREADD (designer receptor exclusively activated by a designer drug). Mol Pharmacol. 2008 Oct;74(4):1119-31.

J Raper et al. Metabolism and Distribution of Clozapine-N-oxide: Implications for Nonhuman Primate Chemogenetics. ACS Chem Neurosci. 2017 Jul 19;8(7):1570-1576.

DF Manvich et al. The DREADD agonist clozapine N-oxide (CNO) is reverse-metabolized to clozapine and produces clozapine-like interoceptive stimulus effects in rats and mice. Sci Rep. 2018 Mar 1;8(1):3840.

CNS Miscellaneous A18

Muscarinic DREADD agonist

Chemical name

4-(8-Chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-1-methylpiperazine 1-oxide

Parent CAS No.

[34233-69-7]

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Clozapine N-oxide - CNO

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