SKI II is an orally bioavailable sphingosine kinase (SK or SphK) inhibitor (IC50 value of 0.5 µM) without competition at the ATP-binding site of SK. Moreover, SKI II showed no inhibition on a small panel of human protein kinases (ERK2 and PKC-α) and a lipid kinase (PI3K). SKI II inhibited cancer cell proliferation, induced apoptosis and inhibited tumor growth in mice.

KEYWORDS: SKI II | supplier | SphK inhibitor | SKI 2 | SKIII | SKI-II | SKI2 | SKI-2 | CAS [312636-16-1] | Sphingosine | SphK1 | SphK2 | Inhibitor | Enzymes | Apoptosis