Bulk Inquiry
CD161
- Soluble in DMSO
- MF: C26H21N5O2
- MW: 435.48
Description
CD161 is a potent, orally active and selective BET bromodomain inhibitor (Ki values of 8.2 nM and 1.4 nM for BRD4 BD1 and BD2, respectively). CD161 inhibits cell growth in acute leukemia cell lines and breast cancer cell lines. Moreover, CD161 has an excellent oral pharmacokinetic profile and, orally administered, effectively inhibits tumor growth in mice.
More Information
| Parent CAS No. | 1627716-22-6 |
|---|---|
| Chemical Name | 4-(6-Methoxy-2-methyl-4-(quinolin-4-yl)-9H-pyrimido[4,5-b]indol-7-yl)-3,5-dimethylisoxazole |
| SMILES | C1C(C2C(C)=NOC=2C)=C(OC)C=C2C3C(C4C=CN=C5C=CC=CC=45)=NC(C)=NC=3NC=12 |
| MFCD | N.A. |
| InChi | InChI=1S/C26H21N5O2/c1-13-23(14(2)33-31-13)19-11-21-18(12-22(19)32-4)24-25(28-15(3)29-26(24)30-21)17-9-10-27-20-8-6-5-7-16(17)20/h5-12H,1-4H3,(H,28,29,30) |
| InChiKey | AEANZCXROGPSBY-UHFFFAOYSA-N |
| CID | 90395752 |
| Short Description | BET inhibitor |
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