SIS3 - Smad3 inhibitor SIS3

Based on 32 reference(s) in Google Scholar 8 10 32

Axon 2764

CAS [521985-36-4]

MF C28H27N3O3
MW 453.53

  • Purity: 98%
  • Soluble in DMSO



SIS3 is a potent and selective inhibitor of Smad3 and TGF-β signaling. Inhibition by SIS3 leads to abrogation of the TGF-β1-induced production of extracellular matrix proteins in normal fibroblasts and scleroderma fibroblasts. Moreover, Smad3 inhibition attenuates resistance to anti-HER2 drugs in HER2-positive breast cancer cells.

KEYWORDS: SIS3 | supplier | Smad3 inhibitor | Smad3 inhibitor SIS3 | SIS-3 | SIS 3 | CAS [521985-36-4] | DNA-RNA | Smad3 | Inhibitor | Transcription Factors | TGF-β | Breast Cancer | HER2

Size Unit Price Stock
5 mg €135.00 In Stock
25 mg €475.00 In Stock
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Size Unit Price Stock
2 x 5 mg €220.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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