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Axon 2764
CAS [521985-36-4]
MF C28H27N3O3MW 453.53
SIS3 is a potent and selective inhibitor of Smad3 and TGF-β signaling. Inhibition by SIS3 leads to abrogation of the TGF-β1-induced production of extracellular matrix proteins in normal fibroblasts and scleroderma fibroblasts. Moreover, Smad3 inhibition attenuates resistance to anti-HER2 drugs in HER2-positive breast cancer cells.
KEYWORDS: SIS3 | supplier | Smad3 inhibitor | Smad3 inhibitor SIS3 | SIS-3 | SIS 3 | CAS [521985-36-4] | DNA-RNA | Smad3 | Inhibitor | Transcription Factors | TGF-β | Breast Cancer | HER2
(E)-1-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one
[521985-36-4]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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