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Axon 2657
CAS [920509-32-6]
MF C17H12Cl2N6O4MW 435.22
Oral, liver-targeted, selective thyroid hormone receptor β-agonist (EC50 value 0.21 µM for THR-β) that is being developed for the treatment of dyslipidemia. MGL-3196 is 28-fold selective for THR-β over THR-α in an in vitro functional coactivator recruitment assay.
KEYWORDS: MGL-3196 | supplier | THR-β agonist | Resmetirom | VIA-3196 | MGL3196 | VIA3196 | CAS [920509-32-6] | Triiodothyronine | thyroid hormone receptor | THR | NR1A | nuclear receptor | dyslipidemia | HDL | LDL | cholesterol | cardiovascular | diabetes | hypercholesterolemic
2-(3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile
[920509-32-6]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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