ML314

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2632

CAS [1448895-09-7]

MF C24H28N4O3
MW 420,50

  • Purity: 100%
  • Soluble in 0.1N HCl(aq) and DMSO

ML314

Description

Brain penetrant nonpeptidic β-Arrestin biased full agonist of the neurotensin NTR1 receptor (EC50 values 2.0 μM and >80 µM for NTR1 and NTR2, respectively). Unlike peptide-based NTR1 agonists, ML314 has no significant response in a Ca2+ mobilization assay. ML314 is a viable, preclinical lead for methamphetamine abuse treatment.

KEYWORDS: ML314 | supplier | NTR1 agonist | ML-314 | CAS [1448895-09-7] | Neurotensin | GPCR | drug abuse | allosteric | β-arrestin | dopamine | CNS | BBB

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5 mg €95.00 In Stock
25 mg €335.00 In Stock
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2 x 5 mg €150.00 In Stock
2 x 25 mg €520.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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