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Axon 2632
CAS [1448895-09-7]
MF C24H28N4O3MW 420.50
Brain penetrant nonpeptidic β-Arrestin biased full agonist of the neurotensin NTR1 receptor (EC50 values 2.0 μM and >80 µM for NTR1 and NTR2, respectively). Unlike peptide-based NTR1 agonists, ML314 has no significant response in a Ca2+ mobilization assay. ML314 is a viable, preclinical lead for methamphetamine abuse treatment.
KEYWORDS: ML314 | supplier | NTR1 agonist | ML-314 | CAS [1448895-09-7] | Neurotensin | GPCR | drug abuse | allosteric | β-arrestin | dopamine | CNS | BBB
2-cyclopropyl-6,7-dimethoxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)quinazoline
[1448895-09-7]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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