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ML314
Axon 2632
CAS:
1448895-09-7
Purity:
100%
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C24H28N4O3
- MW: 420.5
Description
Brain penetrant nonpeptidic β-Arrestin biased full agonist of the neurotensin NTR1 receptor (EC50 values 2.0 μM and >80 µM for NTR1 and NTR2, respectively). Unlike peptide-based NTR1 agonists, ML314 has no significant response in a Ca2+ mobilization assay. ML314 is a viable, preclinical lead for methamphetamine abuse treatment.
More Information
| Parent CAS No. | 1448895-09-7 |
|---|---|
| Chemical Name | 2-cyclopropyl-6,7-dimethoxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)quinazoline |
| SMILES | N1=C2C(C=C(OC)C(OC)=C2)=C(N2CCN(C3=CC=CC=C3OC)CC2)N=C1C1CC1 |
| MFCD | N.A. |
| InChi | InChI=1S/C24H28N4O3/c1-29-20-7-5-4-6-19(20)27-10-12-28(13-11-27)24-17-14-21(30-2)22(31-3)15-18(17)25-23(26-24)16-8-9-16/h4-7,14-16H,8-13H2,1-3H3 |
| InChiKey | SWEOAXMICIJCQC-UHFFFAOYSA-N |
| CID | 53245590 |
| Short Description | NTR1 agonist |
References
- LS Barak et al. ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine Abuse. ACS Chem Biol. 2016 Jul 15;11(7):1880-90.
- S Peddibhotla et al. Discovery of ML314, a Brain Penetrant Non-Peptidic β-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor. ACS Med Chem Lett. 2013 Jul 20;4(9):846-851.
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