Small molecule enhancer of rapamycin that enhances the clearance of mutant aggregate-prone proteins by autophagy in mammalian cell models of Huntington’s and Parkinson’s disease, independent of mTOR and Atg5 pathways. SMER28 also promotes reprogramming of fibroblasts (the conversion efficiency for adult tail-tip fibroblasts in particular) into neural stem cells, if combined with RG108 (Axon 1691) and Parnate.

KEYWORDS: SMER 28 | supplier | Autophagy inducer; SMER | SMER28 | SMER-28 | CAS [307538-42-7] | Small molecule enhancer of rapamycin | SMER | clearance | Huntington’s | Parkinson’s | reprogramming | fibroblasts | neural stem cells