Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2627

CAS [307538-42-7]

MF C11H10BrN3
MW 264.12

  • Purity: 99%
  • Soluble in 0.1N HCl(aq) and DMSO



Small molecule enhancer of rapamycin that enhances the clearance of mutant aggregate-prone proteins by autophagy in mammalian cell models of Huntington’s and Parkinson’s disease, independent of mTOR and Atg5 pathways. SMER28 also promotes reprogramming of fibroblasts (the conversion efficiency for adult tail-tip fibroblasts in particular) into neural stem cells, if combined with RG108 (Axon 1691) and Parnate.

KEYWORDS: SMER 28 | supplier | Autophagy inducer; SMER | SMER28 | SMER-28 | CAS [307538-42-7] | Small molecule enhancer of rapamycin | SMER | clearance | Huntington’s | Parkinson’s | reprogramming | fibroblasts | neural stem cells

Size Unit Price Stock
10 mg €80.00 In Stock
50 mg €280.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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