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Axon 2598
CAS [1613028-81-1]
MF C31H32BrNO4S2MW 626.62
LXR inverse agonist that induces LXR-corepressor interaction inhibiting the Warburg effect and lipogenesis in cancer cells by reducing glycolytic and lipogenic gene expression. SR 9243 induced apoptosis in tumors without inducing weight loss, hepatotoxicity, or inflammation. Moreover, SR 9243 may mediate tumor ‘‘unmasking’’ via downregulation of the immune-suppressive effects of LXR ligands within the tumor microenvironment. Close analogue of GSK 2033 (Axon 2363)
KEYWORDS: SR 9243 | supplier | LXR inverse agonist | SR9243 | CAS [1613028-81-1] | Metabolism | LXR | Inverse agonist | nuclear | Receptors | NR1H | Warburg effect | lipogenesis | cancer cells | glycolytic | lipogenic | gene expression | apoptosis | tumor unmasking
N-(3-bromophenethyl)-2,4,6-trimethyl-N-((3'-(methylsulfonyl)biphenyl-4-yl)methyl)benzenesulfonamide
[1613028-81-1]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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