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SR 9243
Axon 2598
CAS:
1613028-81-1
Purity:
99%
- Soluble in DMSO
- MF: C31H32BrNO4S2
- MW: 626.62
Description
LXR inverse agonist that induces LXR-corepressor interaction inhibiting the Warburg effect and lipogenesis in cancer cells by reducing glycolytic and lipogenic gene expression. SR 9243 induced apoptosis in tumors without inducing weight loss, hepatotoxicity, or inflammation. Moreover, SR 9243 may mediate tumor ‘‘unmasking’’ via downregulation of the immune-suppressive effects of LXR ligands within the tumor microenvironment.
Close analogue of GSK 2033 (Axon 2363)
More Information
| Parent CAS No. | 1613028-81-1 |
|---|---|
| Chemical Name | N-(3-bromophenethyl)-2,4,6-trimethyl-N-((3'-(methylsulfonyl)biphenyl-4-yl)methyl)benzenesulfonamide |
| SMILES | C1(S(N(CCC2=CC=CC(Br)=C2)CC2=CC=C(C3=CC=CC(S(C)(=O)=O)=C3)C=C2)(=O)=O)=C(C)C=C(C)C=C1C |
| MFCD | MFCD29049514 |
| InChi | InChI=1S/C31H32BrNO4S2/c1-22-17-23(2)31(24(3)18-22)39(36,37)33(16-15-25-7-5-9-29(32)19-25)21-26-11-13-27(14-12-26)28-8-6-10-30(20-28)38(4,34)35/h5-14,17-20H,15-16,21H2,1-4H3 |
| InChiKey | FYQFEJFTCLKXTQ-UHFFFAOYSA-N |
| CID | 76073169 |
| Short Description | LXR inverse agonist |
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