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GSK 137647A
Axon 2582
CAS:
349085-82-1
Purity:
99%
- Soluble in DMSO and EtOH
- MF: C16H19NO3S
- MW: 305.39
Description
Potent FFA4/GPR120 agonist (pEC50 value 6.3 nM for hFFA4) with >100-fold selectivity over a panel of 65 targets including FFA1-FFA3. GSK137647A reproduces the secretion of active GLP-1 mediated by long-chain Fas (LCFAs), especially ALA.
More Information
| Parent CAS No. | 349085-82-1 |
|---|---|
| Chemical Name | N-mesityl-4-methoxybenzenesulfonamide |
| SMILES | C1(S(NC2=C(C)C=C(C)C=C2C)(=O)=O)=CC=C(OC)C=C1 |
| MFCD | MFCD02007969 |
| InChi | InChI=1S/C16H19NO3S/c1-11-9-12(2)16(13(3)10-11)17-21(18,19)15-7-5-14(20-4)6-8-15/h5-10,17H,1-4H3 |
| InChiKey | FQUAFMNPXPXOJE-UHFFFAOYSA-N |
| CID | 743974 |
| Short Description | FFA4/GPR120 agonist |
References
- SM Sparks et al. Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120). Bioorg Med Chem Lett. 2014 Jul 15;24(14):3100-3.
- C Martin et al. Lipid-mediated release of GLP-1 by mouse taste buds from circumvallate papillae: putative involvement of GPR120 and impact on taste sensitivity. J Lipid Res. 2012 Nov;53(11):2256-65.
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