Dimethylcelecoxib, 2,5- - DMC

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2496

CAS [457639-26-8]

MF C18H16F3N3O2S
MW 395.40

  • Purity: 100%
  • Soluble in DMSO

Dimethylcelecoxib, 2,5-

Description

Celecoxib analog that lacks COX-2 inhibitory activity but exhibits anti-tumor properties; DMC reduced growth and initiated apoptotic cell death in several MM cell lines. Mechanistically, DMC down-regulates critical components of the cell-cycle machinery (cyclins A and B); blocks the activity of important mitogenic and survival pathways (MEK, NF-κB, STAT3, survivin); and leads to increased caspase activity. Moreover, DMC quite potently mimics the ability of celecoxib to stimulate the endoplasmic reticulum stress response (ESR) and subsequent cell death .
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