Piperlongumine - Piplartine

Based on 230 publications in PubMed 9 10 230

Axon 2488

CAS [20069-09-4]

MF C17H19NO5
MW 317.34

  • Purity: 99%
  • Soluble in DMSO



Natural alkaloid with potent cytotoxic activity which has been related to an increased reactive oxygen species (ROS) generation in cancer cells (through direct GSTP1 interaction), down-regulation of nuclear factor-kB (NF-kB) activation and induction of rapid depletion of the androgen receptor (AR) in prostate cancer cells. Moreover, Piperlongumine (or Piplartine) was found to induce apoptosis and autophagy through modulation of the PI3K/Akt/mTOR pathway in human lung cancer cells, and potently inhibited ligand-stimulated STAT3 nuclear translocation.

KEYWORDS: Piperlongumine | supplier | Apoptosis inducer/GSTP1 inhibitor | Piplartine | CAS [20069-09-4] | Glutathion (GSH) | GSTP | STAT3 | Inhibitor | ROS | reactive oxygen species | ubiquitin | UPS | proteasome | NF-kB | androgen receptor | apoptosis | autophagy | PI3K/Akt/mTOR | JNK | STAT3 | Natural alkaloid

Natural alkaloid with potent cytotoxic activity

Chemical name


Parent CAS No.


Size Unit Price Stock
5 mg €65.00 In Stock
25 mg €165.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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