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HG-9-91-01
Axon 2311
CAS:
1456858-58-4
Purity:
98%
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C32H37N7O3
- MW: 567.68
Description
HG-9-91-01 is a potent salt-inducible kinase (SIK) inhibitor with IC50 values of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3, respectively. It is used to investigate SIK-dependent phosphorylation pathways and inflammatory transcriptional regulation.
SIK kinases regulate CREB coactivator activity, macrophage polarization and anti-inflammatory gene expression downstream of innate immune signaling. HG-9-91-01 is relevant for studying SIK-controlled cytokine programs and kinase-selective immunomodulation.
Key Features
- Potent SIK family inhibitor
- IC50: 0.92 nM at SIK1
- Inhibits SIK2 and SIK3 in the low-nanomolar range
- Probe for SIK-dependent inflammatory transcription
Applications
- SIK kinase pharmacology
- Macrophage and innate immune signaling studies
- CREB coactivator pathway assays
- Anti-inflammatory mechanism research
More Information
| Parent CAS No. | 1456858-58-4 |
|---|---|
| Chemical Name | 1-(2,4-Dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-(6-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yl)urea |
| SMILES | N(C1C=CC(N2CCN(C)CC2)=CC=1)C1N=CN=C(N(C2C(OC)=CC(OC)=CC=2)C(NC2C(C)=CC=CC=2C)=O)C=1 |
| MFCD | MFCD28167714 |
| InChi | InChI=1S/C32H37N7O3/c1-22-7-6-8-23(2)31(22)36-32(40)39(27-14-13-26(41-4)19-28(27)42-5)30-20-29(33-21-34-30)35-24-9-11-25(12-10-24)38-17-15-37(3)16-18-38/h6-14,19-21H,15-18H2,1-5H3,(H,36,40)(H,33,34,35) |
| InChiKey | UYUHRKLITDJEHB-UHFFFAOYSA-N |
| CID | 78357808 |
| Short Description | SIK inhibitor |
HG-9-91-01
SIK family inhibitor
Anti-inflammatory
Toll-like receptors
SIK family
Inhibitor
SIK kinase pharmacology
Macrophage and innate immune signaling studies
CREB coactivator pathway assays
Anti-inflammatory mechanism research
innate immunity
inflammation
cytokine signaling
macrophage biology
kinase signaling
receptor selectivity
signal transduction
transcriptional regulation
CAS 1456858-58-4
CAS 1876462-76-8
Axon Medchem
Axon 2311
Supplier
Vendor
References
- K Clark et al. Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16986-91.
- TB Sundberg et al. Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells. Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12468-73.
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