HG-9-91-01

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2311

CAS [1456858-58-4]

MF C32H37N7O3
MW 567.68

Purity: 98%
Soluble in 0.1N HCl(aq) and DMSO

HG-9-91-01

Description

HG-9-91-01 is a potent and selective SIK inhibitor with IC50 values of 0.92, 6.6 and 9.6 nM for SIK1, SIK2 and SIK3, respectively.

K Clark et al. Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16986-91.

TB Sundberg et al. Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells. Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12468-73.

Potent and selective SIK inhibitor

Chemical name

1-(2,4-Dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-(6-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yl)urea

Parent CAS No.

[1456858-58-4]

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3041	ARN 3236	Potent, selective, ATP-competitive, and orally available inhibitor of SIK2		€80.00

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HG-9-91-01

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HG-9-91-01

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