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ARN 3236
Axon 3041
CAS:
1613710-01-2
Purity:
98%
- Soluble in DMSO
- MF: C19H16N2O2S
- MW: 336.41
Description
ARN 3236 is a potent, selective, ATP-competitive, and orally available inhibitor of SIK2 (IC50 value of < 1 nM) and inhibits SIK1 and SIK3 with IC50 values of 21.63 and 6.63 nM, respectively. Moreover, ARN 3236 inhibits ovarian cancer cell growth and sensitizes ovarian cancer cells and xenografts to paclitaxel by inhibiting centrosome splitting and AKT/survivin signaling.
More Information
| Parent CAS No. | 1613710-01-2 |
|---|---|
| Chemical Name | 3-(2,4-Dimethoxyphenyl)-4-(thiophen-3-yl)-1H-pyrrolo[2,3-b]pyridine |
| SMILES | C1C(C2C=CSC=2)=C2C(C3C=CC(OC)=CC=3OC)=CNC2=NC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C19H16N2O2S/c1-22-13-3-4-15(17(9-13)23-2)16-10-21-19-18(16)14(5-7-20-19)12-6-8-24-11-12/h3-11H,1-2H3,(H,20,21) |
| InChiKey | WEHOIIGXTMKVRG-UHFFFAOYSA-N |
| CID | 74766530 |
| Short Description | SIK2 inhibitor |
References
- MS Lombardi et al. SIK inhibition in human myeloid cells modulates TLR and IL-1R signaling and induces an anti-inflammatory phenotype. J Leukoc Biol. 2016 May;99(5):711-21.
- J Zhou et al. A Novel Compound ARN-3236 Inhibits Salt-Inducible Kinase 2 and Sensitizes Ovarian Cancer Cell Lines and Xenografts to Paclitaxel. Clin Cancer Res. 2017 Apr 15;23(8):1945-1954.
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