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CX 6258 hydrochloride

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2305

CAS [1353859-00-3]

MF C26H24ClN3O3.HCl
MW 498.40

  • Purity: 99%
  • Soluble in DMSO

CX 6258 hydrochloride

Description

Potent, selective, and orally efficacious pan-Pim kinases inhibitor (IC50 values 5 nM, 25 nM, and 16 nM for Pim-1, Pim-2, and Pim-3 respectively) with 5-40 fold selectivity over Flt-3 (IC50 values 0.134 μM).CX 6258 exhibited dose dependent efficacy in a mouse MV-4-11 xenograft study, with a 50 mg/kg dose producing 45% tumor growth inhibition (TGI) and a 100 mg/kg dose producing 75% TGI, and was well tolerated throughout the study.
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5 mg €99.00 In Stock
25 mg €320.00 In Stock
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2 x 5 mg €160.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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