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(+)-ZK 216348
- Optical Purity: 99.8%
- Soluble in DMSO
- MF: C24H23F3N2O5
- MW: 476.45
Description
More Information
| Parent CAS No. | 669073-68-1 |
|---|---|
| Chemical Name | (+)-4-(2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-N-(4-methyl-1-oxo-1H-benzo[d][1,2]oxazin-6-yl)-2-(trifluoromethyl)pentanamide |
| SMILES | O1C2=C(C(C)(C)CC(C(F)(F)F)(O)C(NC3=CC=C4C(=O)ON=C(C)C4=C3)=O)C=CC=C2CC1 |
| MFCD | N.A. |
| InChi | InChI=1S/C24H23F3N2O5/c1-13-17-11-15(7-8-16(17)20(30)34-29-13)28-21(31)23(32,24(25,26)27)12-22(2,3)18-6-4-5-14-9-10-33-19(14)18/h4-8,11,32H,9-10,12H2,1-3H3,(H,28,31) |
| InChiKey | VRZVKIJRJRBQJT-UHFFFAOYSA-N |
| CID | 9805004 |
| Short Description | Glucocorticoid agonist |
References
- S. Jaroch te al. Discovery of quinolines as selective glucocorticoid receptor agonists. Bioorg. Med. Chem. Lett. 2010, 20, 5835-5838.
- H .Schäcke et al. Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects. Proc. Natl. Acad. Sci. USA. 2004, 101, 227-232.
- K.C. Reuter et al. Selective glucocorticoid receptor agonists for the treatment of inflammatory bowel disease: studies in mice with acute trinitrobenzene sulfonic acid colitis. J. Pharmacol. Exp. Ther. 2012, 341, 68-80.
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