ZK 216348, (+)-

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2239

CAS [669073-68-1]

MF C24H23F3N2O5
MW 476.45

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in DMSO

ZK 216348, (+)-

Description

Selective nonsteroidal glucocorticoid receptor (GR) agonist for the treatment of experimental colitis with IC50 values of 20, 20, and 80 nM for GR, Progesterone (PR) and Mineralocorticoid (MR) receptors respectively. (+)-ZK 216348 shows antiinflammatory activity comparable to prednisolone for both systemic and topical application, with a significant dissociation between transrepression and transactivation of antiinflammatory effects both in vitro and in vivo.(+)-ZK 216348 showed no negative effects on intestinal epithelial migration or proliferation. (-)-ZK 216348 is completely inactive (IC50 >1000 nM for GR, PR, and MR.
Order
Size Unit Price Stock
2 mg €125.00 In Stock
5 mg €205.00 In Stock
Need more? Bulk Inquiry

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

Please wait...