Bulk Inquiry
Flumethasone
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C22H28F2O5
- MW: 410.45
Description
Flumethasone is a selective and potent topical glucocorticoid receptor agonist with a reported IC50 value of 0.26 nM for human glucocorticoid receptor. It is used as an anti-inflammatory corticosteroid research compound.
Glucocorticoid receptor activation regulates transcriptional programs involved in inflammation, immune suppression and allergic responses. Flumethasone is useful for studying corticosteroid signaling and glucocorticoid receptor pharmacology.
Key Features
- Potent human glucocorticoid receptor agonist
- Reported IC50: 0.26 nM for human GR
- Topical corticosteroid research compound
- Anti-inflammatory and immunomodulatory activity
Applications
- Glucocorticoid receptor pharmacology
- Inflammation and immune response studies
- Corticosteroid signaling research
- Allergy and autoimmune pathway models
More Information
| Parent CAS No. | 2135-17-3 |
|---|---|
| Chemical Name | (6S,9R,10S,11S,13S,16R,17R)-6,9-Difluoro-11,17-dihydroxy-17-(2-hydroxy-acetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-cyclopenta[a]phenanthren-3-one |
| SMILES | [C@@]12([H])C[C@@H](C3=CC(C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@]1(C)[C@@]([C@H](C)C[C@@]21[H])(O)C(=O)CO)=O)F |&1:0,3,9,11,13,16,18,19,22,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C22H28F2O5/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-19(15,2)21(14,24)17(27)9-20(13,3)22(11,29)18(28)10-25/h4-5,7,11,13-14,16-17,25,27,29H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19+,20+,21+,22+/m1/s1 |
| InChiKey | WXURHACBFYSXBI-GQKYHHCASA-N |
| CID | 16490 |
| Short Description | Glucocorticoid agonist |
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