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Axon 1170
- (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxo-androsta-1,4-diene-17-carboxylic acid,
- No solubility data
- MF: C21H26F2O5
- MW: 396.42
Description
Axon 1170 is a steroid derivative and precursor for fluticasone-related compounds. It is best positioned as a synthetic intermediate for corticosteroid analogue preparation rather than as a characterized pharmacological probe.
Steroid intermediates are important in corticosteroid medicinal chemistry and analogue synthesis. Axon 1170 can support preparation of fluticasone-related structures and steroid structure-activity relationship workflows.
Key Features
- Steroid derivative
- Precursor for fluticasone-related chemistry
- No defined receptor or enzyme target assigned
- Useful synthetic intermediate for corticosteroid analogues
Applications
- Steroid synthesis
- Fluticasone analogue preparation
- Corticosteroid medicinal chemistry
- Structure-activity relationship research
More Information
| Parent CAS No. | 28416-82-2 |
|---|---|
| Chemical Name | (6S,9R,10S,11S,13S,16R,17R)-6,9-Difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid |
| MFCD | MFCD09832931 |
| Short Description | Building Block |
References
- Liao, Y. et al. Synthesis and pharmacological evaluation of triflate-substituted analogues of Clozapine: Identification of a novel atypical neuroleptic. J. Med. Chem. 1997, 40, 4146-4153.
- Y. Liao et al. New sulfonyloxy piperazinyldibenzazapines as potential atypical antipsychotics: chemistry and pharmacological evaluation. J. Med. Chem. 1999,42, 2235-2244.
- Jackson, D; Wikström, H; Liao, Y. Is clozapine an (partial) agonist at both dopamine D1 and D2 receptors? Psychopharm. 1998, 138, 213-214.
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