ONO 5334

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2156

CAS [868273-90-9]

MF C21H34N4O4S
MW 438.58

Purity: 98%
Optical purity: Optically pure
Soluble in DMSO

ONO 5334

Description

Potent and orally available inhibitor of cathepsin K (Ki values of 0.1 nM, 0.049 nM and 0.85 nM for human, rabbit and rat respectively). ONO 5334 dose depedently suppresses human osteoclast-mediated bone resorption in vitro, and reduced PTHrP-induced increase in plasma calcium with significant effect (86% reduction) after oral administration in TPTX pretreated rats.

R. Eastell et al. Effect of ONO-5334 on Bone Mineral Density and Biochemical Markers of Bone Turnover in Postmenopausal Osteoporosis: 2-Year Results From the OCEAN Study. J. Bone Miner Res. 2014, 29, 458-466.

Y. Ochi et al. Effects of ONO-5334, a novel orally-active inhibitor of cathepsin K, on bone metabolism. Bone. 2011, 49, 1351-1356.

Potent and orally available inhibitor of cathepsin K

Chemical name

N-((R)-3-((Z)-2-((R)-3,4-dimethylthiazolidin-2-ylidene)hydrazinyl)-2,3-dioxo-1-(tetrahydro-2H-pyran-4-yl)propyl)cycloheptanecarboxamide

Parent CAS No.

[868273-90-9]

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Size	Unit Price	Stock
2 mg	€140.00	In Stock
5 mg	€300.00	In Stock

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Axon ID	Name	Description	From price
1771	MK 0822	Inhibitor of cathepsin K		€60.00
2154	Balicatib	Selective inhibitor of cathepsin K		€50.00

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