INNO 406 - Bafetinib

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2121

CAS [859212-16-1]

MF C30H31F3N8O
MW 576.62

Purity: 99%
Optical purity: Optically pure
Soluble in 0.1N HCl(aq) and DMSO

INNO 406

Description

Orally bioavailable dual Bcr-Abl and Lyn kinase inhibitor with anti-CML efficacy; orally bioavailable; more potent (>10 times) than Imatinib; highly recommended Abl inhibitor in treating chronic myeloid leukaemia (CML)

A Yokota et al. INNO-406, a novel BCR-ABL/Lyn dual tyrosine kinase inhibitor, suppresses the growth of Ph+ leukemia cells in the central nervous system, and cyclosporine A augments its in vivo activity. Blood, 2007, 109(1), 306-314.

H Kantarjian et al. Phase 1 study of INNO-406, a dual Abl/Lyn kinase inhibitor, in Philadelphia chromosome-positive leukemias after imatinib resistance or intolerance. Cancer, 2010, 116(11), 2665-72.

JC Uitdehaag et al. A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets. Br. J. Pharmacol. 2012, 166, 858–876.

Dual Bcr-Abl and Lyn kinase inhibitor

Chemical name

(S)-N-(3-(4,5'-bipyrimidin-2-ylamino)-4-methylphenyl)-4-((3-(dimethylamino)pyrrolidin-1-yl)methyl)-3-(trifluoromethyl)benzamide

Parent CAS No.

[859212-16-1]

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Size	Unit Price	Stock
2 mg	€85.00	In Stock
5 mg	€135.00	In Stock
25 mg	€475.00	In Stock

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INNO 406 - Bafetinib

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INNO 406 - Bafetinib

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