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PF 06465469
Axon 2110
CAS:
1407966-77-1
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C30H33N7O2
- MW: 523.63
Description
PF 06465469 is a potent covalent inhibitor of interleukin-2-inducible T cell kinase (ITK) with nanomolar potency. It is used to suppress ITK-dependent signaling downstream of the T cell receptor.
ITK is a TEC-family kinase involved in T cell activation, cytokine production and Th2-biased immune responses. PF 06465469 is relevant for immune pharmacology, inflammatory disease research and covalent kinase inhibitor profiling.
Key Features
- Potent covalent ITK inhibitor
- Targets T cell receptor-associated kinase signaling
- Nanomolar biochemical potency reported
- Useful for studying T cell activation pathways
Applications
- ITK kinase assays
- T cell receptor signaling studies
- Th2 cytokine pathway research
- Immunology and inflammation models
More Information
| Parent CAS No. | 1407966-77-1 |
|---|---|
| Chemical Name | (R)-3-(1-(1-acryloylpiperidin-3-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-isopropyl-3-methylphenyl)benzamide |
| extra_info | . |
| SMILES | C(NC1=CC=C(C(C)C)C(C)=C1)(=O)C1=CC=CC(C2C3=C(N)N=CN=C3N([C@@H]3CCCN(C(=O)C=C)C3)N=2)=C1 |&1:27,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C30H33N7O2/c1-5-25(38)36-13-7-10-23(16-36)37-29-26(28(31)32-17-33-29)27(35-37)20-8-6-9-21(15-20)30(39)34-22-11-12-24(18(2)3)19(4)14-22/h5-6,8-9,11-12,14-15,17-18,23H,1,7,10,13,16H2,2-4H3,(H,34,39)(H2,31,32,33)/t23-/m1/s1 |
| InChiKey | CGJVMKJGKFEHTL-HSZRJFAPSA-N |
| CID | 71450146 |
| Short Description | ITK inhibitor |
PF 06465469
potent covalent ITK inhibitor
covalent ITK
Inhibitor
ITK kinase assays
T cell receptor signaling studies
Th2 cytokine pathway research
Immunology and inflammation models
immunology
inflammation
cytokine signaling
T-cell biology
kinase signaling
signal transduction
Axon Medchem
Axon 2110
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