Order

Size
Price
Stock
Qty

Special Offers

Size
Price
Stock
Qty

EMPA

Axon 2012
CAS:  680590-49-2
Purity:  99%
  • Soluble in DMSO and EtOH
  • MF:  C23H26N4O4S
  • MW:  454.54

Description

EMPA is a highly potent and selective orexin type 2 receptor (OX2R/HCRTR2) antagonist with reported Ki activity of 1 nM at OX2 and >900 nM at OX1.

Orexin receptors regulate arousal, sleep-wake stability, reward pathways and autonomic functions. EMPA is useful for selectively probing OX2 receptor pharmacology in CNS signaling and sleep-related experimental models.

Key Features

  • Selective OX2 receptor antagonist
  • Reported Ki: 1 nM at OX2
  • Strong selectivity over OX1 receptor binding
  • Useful for orexin system pharmacology

Applications

  • OX2 receptor binding assays
  • Sleep-wake pathway research
  • CNS neuropeptide signaling studies
  • Orexin receptor antagonist profiling

More Information

Parent CAS No. 680590-49-2
Chemical Name N-ethyl-2-(N-(6-methoxypyridin-3-yl)-2-methylphenylsulfonamido)-N-(pyridin-3-ylmethyl)acetamide
SMILES C(N(CC)CC1=CC=CN=C1)(=O)CN(C1=CC=C(OC)N=C1)S(C1=CC=CC=C1C)(=O)=O
MFCD N.A.
InChi InChI=1S/C23H26N4O4S/c1-4-26(16-19-9-7-13-24-14-19)23(28)17-27(20-11-12-22(31-3)25-15-20)32(29,30)21-10-6-5-8-18(21)2/h5-15H,4,16-17H2,1-3H3
InChiKey KJPHTXTWFHVJIG-UHFFFAOYSA-N
CID 9981404
Short Description OX2 antagonist

Related Products

AXON ID NAME FROM PRICE
2095 SB 334867

From $99.00

2192 SB 674042

From $108.90

2744 TCS1102

From $99.00

3805 MK-3697

From Inquiry

Other Categories

More Categories

Axon Ligands™ for Cell Signaling & Oncology

Axon Ligand™ for Stem Cell Research 

Axon Ligands™ for Epigenetic Research 

Loading...