CP 100356 hydrochloride

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1654

CAS [142715-48-8]

MF C31H36N4O6.HCl
MW 597.10

Purity: 98%
Soluble in DMSO

CP 100356 hydrochloride

Description

Potent inhibitor of P-glycoprotein (P-gp), with Ki to be 58 and 94 nM for 1a and 1b isomers of P-gp; an in vivo probe to selectively assess MDR1/BCRP-mediated drug efflux

C Wandel et al. P-glycoprotein and cytochrome P-450 3A inhibition: dissociation of inhibitory potencies. Cancer Res. 1999, 59, 3944.

JC Taylor et al. The equilibrium and kinetic drug binding properties of the mouse P-gp1a and P-gp1b P-glycoproteins are similar. Br. J. Cancer 1999, 81(5), 783-789.

AS Kalgutkar et al. N-(3,4-dimethoxyphenethyl)-4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2[1H]-yl)-6,7-dimethoxyquinazolin-2-amine (CP-100,356) as a "chemical knock-out equivalent" (...). J. Pharm. Sci. 2009, 98, 4914.

P-gp inhibitor

Chemical name

4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-N-(3,4-dimethoxyphenethyl)-6,7-dimethoxyquinazolin-2-amine

Parent CAS No.

[142716-85-6]

Order

Size	Unit Price	Stock
5 mg	€90.00	In Stock
10 mg	€140.00	In Stock
50 mg	€560.00	In Stock

Need more? Bulk Inquiry

Related Products

Axon ID	Name	Description
1409	KO 143	BCRP inhibitor	€60.00
1839	Zosuquidar trihydrochloride	Inhibitor of P-glycoprotein	€95.00
1896	Elacridar hydrochloride	P-gp inhibitor (3rd generation ABCB1 modulator)	€80.00
1960	Tariquidar	Inhibitor of P-glycoprotein (P-gp, ABCB1)	€135.00
2508	KS 176	Inhibitor of the ABC-transporter BCRP	€135.00
2591	MC70 hydrochloride	Potent P-gp inhibitor with good selectivity towards BCRP pump	€125.00
3222	Reversan	Potent, selective and non-toxic MRP1 inhibitor	€90.00
3564	ABCA1 inducer compound G	ABCA1 inducer targeting OSBPL7	€150.00
3784	PGP-4008	Selective P-glycoprotein (Pgp) inhibitor	€120.00

Customer Support

Customer Services

About Axon Medchem

Contact Us

CP 100356 hydrochloride

Description

Chemical name

Parent CAS No.

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Customer Support

Customer Services

About Axon Medchem

Contact Us

CP 100356 hydrochloride

Description

Chemical name

Parent CAS No.

Related Products

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Send us a message

Contact Us