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Orvepitant maleate

 - GW 823296B  - GW 823296X maleate
Axon 1618
  • Parent CAS:  579475-18-6
  • Optical Purity:  >98% e.e.
  • Soluble in water and DMSO
  • MF:  C31H35F7N4O2.C4H4O4
  • MW:  744.7

Description

Orvepitant maleate is a neurokinin-1 (NK1) receptor antagonist that blocks substance P-mediated signaling.

NK1 receptor pathways are involved in stress responses, affective behavior, nausea and pain-related neuropeptide signaling. Orvepitant is useful for studying NK1 receptor pharmacology in anxiety, depression and emesis-related research models.

Key Features

  • NK1 receptor antagonist
  • Blocks substance P neuropeptide signaling
  • Relevant to stress, mood and emesis pathway research
  • Useful for central neurokinin receptor pharmacology

Applications

  • NK1 receptor pharmacology
  • Anxiety and depression model studies
  • Substance P signaling assays
  • Emesis and stress-response pathway research

More Information

Parent CAS No. 579475-18-6
Chemical Name (2R,4S)-N-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)-2-(4-fluoro-2-methylphenyl)-N-methyl-4-((S)-6-oxohexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)piperidine-1-carboxamide maleate
SMILES C1(C(F)(F)F)=CC([C@@H](C)N(C)C(=O)N2[C@@H](C3C=CC(F)=CC=3C)C[C@@H](N3C[C@@]4(CCC(=O)N4CC3)[H])CC2)=CC(C(F)(F)F)=C1.O=C(O)/C=CC(O)=O |&1:7,14,24,27,r|
MFCD N.A.
InChi InChI=1S/C31H35F7N4O2.C4H4O4/c1-18-12-23(32)4-6-26(18)27-16-24(40-10-11-41-25(17-40)5-7-28(41)43)8-9-42(27)29(44)39(3)19(2)20-13-21(30(33,34)35)15-22(14-20)31(36,37)38;5-3(6)1-2-4(7)8/h4,6,12-15,19,24-25,27H,5,7-11,16-17H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t19-,24+,25+,27-;/m1./s1
InChiKey IPACOHTZCSBGBV-WUXDIRCFSA-N
CID 44225656
Short Description NK1 antagonist

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