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PPP hydrochloride
- Parent CAS: 92321-29-4
- Soluble in water
- MF: C14H21N.HCl
- MW: 239.78
Description
PPP hydrochloride is a selective mechanism-based inactivator of human cytochrome P450 2B6.
CYP2B6 contributes to metabolism of many xenobiotics and therapeutic agents. PPP hydrochloride is useful for probing CYP2B6-mediated metabolism, enzyme inactivation kinetics and drug-drug interaction risk in in vitro pharmacology systems.
Key Features
- Selective inactivator of human CYP2B6
- Tool compound for cytochrome P450 phenotyping
- Useful for mechanism-based enzyme inactivation studies
- Supports assessment of CYP2B6-mediated metabolism
Applications
- Drug metabolism and pharmacokinetic research
- CYP2B6 enzyme assays
- Drug-drug interaction model studies
- Microsomal metabolism phenotyping
More Information
| Parent CAS No. | 92321-29-4 |
|---|---|
| Chemical Name | 1-(2-phenylpropan-2-yl)piperidine hydrochloride |
| SMILES | C1C=C(C(N2CCCCC2)(C)C)C=CC=1.Cl |
| MFCD | MFCD01700939 |
| InChi | InChI=1S/C14H21N.ClH/c1-14(2,13-9-5-3-6-10-13)15-11-7-4-8-12-15;/h3,5-6,9-10H,4,7-8,11-12H2,1-2H3;1H |
| InChiKey | DZQJVYVJEDNFGD-UHFFFAOYSA-N |
| CID | 210767 |
| Short Description | CYP2B6 inhibitor |
References
- RL Walsky and RS Obach. A Comparison of PPP, 1,1′,1″-Phosphinothioylidynetrisaziridine (ThioTEPA), Clopidogrel, and Ticlopidine as Selective Inactivators of Human Cytochrome P450 2B6. Drug Metab. Dsipos. (DMD). 2007, 35(11), 2053-2059.
- J Chun et al. Mechanism-based inactivation of cytochromes P450 2B1 and P450 2B6 by 2-phenyl-2-(1-piperidinyl)propane. Drug Metab Dispos. 2000, 28(8), 905-911.
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