SSR 504734

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1549

CAS [615571-23-8]

MF C20H20ClF3N2O.HCl
MW 433.29

Purity: 99%
Optical purity: optical pure
Soluble in water and DMSO

SSR 504734

Description

A potent, selective and orally active GlyT-1 inhibitor, blocked the ex vivo uptake of glycine rapidly, reversibly, and for a long duration; exhibiting activity in animal models of schizophrenia, anxiety and depression

G Depoortere et al. Neurochemical, electrophysiological and pharmacological profiles of the selective inhibitor of the glycine transporter-1 SSR504734, a potential new type of antipsychotic. Neuropsychopharmacology 2005, 30, 1963–1985.

K Hashimoto. Glycine Transporter Inhibitors as Therapeutic Agents for Schizophrenia. Recent Pat. CNS Drug Discov. 2006, 1, 43-53.

CNS GlyT Unclassified

GlyT-1 inhibitor

Chemical name

2-chloro-3-(trifluoromethyl)-N-((S)-phenyl((S)-piperidin-2-yl)methyl)benzamide hydrochloride

Parent CAS No.

[742693-38-5]

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2 mg	€110.00	In Stock
5 mg	€190.00	In Stock

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SSR 504734

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