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CNF 2024
- BIIB 021
- Soluble in DMSO
- MF: C14H15ClN6O
- MW: 318.76
Description
CNF 2024 (BIIB-021) is an orally active Hsp90 inhibitor used to disrupt heat shock protein 90 chaperone function.
Inhibiting Hsp90 promotes degradation of client proteins that drive proliferation, survival and stress adaptation in tumor cells. CNF 2024 is useful for research on chaperone-dependent oncogenic signaling and pharmacological modulation of proteostasis.
Key Features
- Orally active Hsp90 inhibitor
- Disrupts chaperone-dependent client protein stability
- Relevant to oncogenic signaling and stress-response biology
- Useful comparator for Hsp90 inhibitor studies
Applications
- Heat shock protein 90 pharmacology
- Proteostasis and client-protein turnover assays
- Cancer cell signaling research
- Chaperone inhibitor profiling
More Information
| Parent CAS No. | 848695-25-0 |
|---|---|
| Chemical Name | 6-Chloro-9-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethyl)-9H-purin-2-ylamine |
| SMILES | N1C(Cl)=C2N=CN(CC3C(C)=C(OC)C(C)=CN=3)C2=NC=1N |
| MFCD | MFCD15528939 |
| InChi | InChI=1S/C14H15ClN6O/c1-7-4-17-9(8(2)11(7)22-3)5-21-6-18-10-12(15)19-14(16)20-13(10)21/h4,6H,5H2,1-3H3,(H2,16,19,20) |
| InChiKey | QULDDKSCVCJTPV-UHFFFAOYSA-N |
| CID | 16736529 |
| Short Description | HSP90 inhibitor |
References
- B Böll et al. Heat Shock Protein 90 Inhibitor BIIB021 (CNF2024) Depletes NF-κB and Sensitizes Hodgkin's Lymphoma Cells for Natural Killer Cell–Mediated Cytotoxicity. Clin. Cancer Res. 2009, 15(16), 5108–16.
- T Taldone et al. Targeting Hsp90: small-molecule inhibitors and their clinical development. Cur. Opin. Pharmacol. 2008, 8(4), 370-374.
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