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SL-145
Axon 3701
CAS:
2051587-62-1
Purity:
97%
- Soluble in DMSO and EtOH
- MF: C28H29NO6
- MW: 475.53
Description
SL-145 is a C-terminal heat shock protein 90 (HSP90) inhibitor. SL-145 elicits anti-tumor and anti-metastatic effects without triggering the heat shock response (HSR) due to its unconventional targeting of the C-terminal region. SL-145 simultaneously inhibits multiple oncogenic signaling pathways including AKT, MEK/ERK, and JAK2/STAT3 in vitro and in vivo.
More Information
| Parent CAS No. | 2051587-62-1 |
|---|---|
| Chemical Name | (6,7-Dimethoxyquinolin-4-yl)(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)methyl cyclopropanecarboxylate |
| SMILES | C1C(OC)=C(OC)C=C2C(C(OC(=O)C3CC3)C3C=CC4OC(C)(C)C=CC=4C=3OC)=CC=NC=12 |
| MFCD | N.A. |
| InChi | InChI=1S/C28H29NO6/c1-28(2)12-10-18-22(35-28)9-8-19(25(18)33-5)26(34-27(30)16-6-7-16)17-11-13-29-21-15-24(32-4)23(31-3)14-20(17)21/h8-16,26H,6-7H2,1-5H3 |
| InChiKey | QXTXWJVPDYIRNM-UHFFFAOYSA-N |
| CID | 134157880 |
| Short Description | HSP90 inhibitor |
References
- HS Kim et al. Synthesis and biological evaluation of C-ring truncated deguelin derivatives as heat shock protein 90 (HSP90) inhibitors. Bioorg Med Chem. 2016 Nov 15;24(22):6082-6093.
- JY Kim et al. A novel HSP90 inhibitor SL-145 suppresses metastatic triple-negative breast cancer without triggering the heat shock response. Oncogene. 2022 Jun;41(23):3289-3297.
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