NVP-AUY922 - VER 52296 | Luminespib

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1542

CAS [747412-49-3]

MF C26H31N3O5
MW 465.54

Purity: 98%
Soluble in DMSO

NVP-AUY922

Description

Highly potent and oral inhibitor of heat shock protein 90 (Hsp90) in vitro and in vivo, with IC50=21 nM in Hsp90 FP binding assay; inhibits proliferation of various human cancer cell lines in vitro, with GI50 average 9 nM

MR Jensen et al. NVP-AUY922: a small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models. Breast Cancer Res. 2008, 10, R33.

SA Eccles et al. NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis. Cancer Res. 2008, 68, 2850.

PA Brough et al. 4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer. J. Med. Chem., 2008, 51 (2), pp 196–218.

T Taldone et al. Targeting Hsp90: small-molecule inhibitors and their clinical development. Cur. Opin. Pharmacol. 2008, 8(4), 370-374.

Hsp90 inhibitor

Chemical name

5-(2,4-Dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide

Parent CAS No.

[747412-49-3]

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5 mg	€75.00	In Stock
25 mg	€225.00	In Stock

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Size	Unit Price	Stock
2 x 5 mg	€100.00	In Stock
2 x 25 mg	€320.00	In Stock

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NVP-AUY922 - VER 52296 | Luminespib

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NVP-AUY922 - VER 52296 | Luminespib

Description

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Parent CAS No.

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