Bulk Inquiry
Sitamaquine tosylate
- WR 6026 tosylate
Axon 1515
- Parent CAS: 57695-04-2
Purity:
99%
- Soluble in DMSO
- MF: C21H33N3O.C7H8O3S
- MW: 515.71
Description
Sitamaquine tosylate (WR-6026) is an orally active antileishmanial compound reported to inhibit mitochondrial complex II, also known as succinate dehydrogenase, in Leishmania promastigotes.
Complex II links the tricarboxylic acid cycle to the respiratory chain and is an important metabolic vulnerability in parasites. Sitamaquine is relevant for investigating parasite mitochondrial bioenergetics, antileishmanial mechanisms and host-pathogen pharmacology.
Key Features
- Antileishmanial compound with mitochondrial mechanism
- Inhibits complex II/succinate dehydrogenase activity in Leishmania models
- Targets parasite respiratory-chain energy metabolism
- Useful for studying mitochondrial vulnerabilities in protozoa
Applications
- Leishmania pharmacology research
- Antiparasitic drug-discovery assays
- Mitochondrial respiration studies
- Parasite bioenergetics and viability models
More Information
| Parent CAS No. | 57695-04-2 |
|---|---|
| Chemical Name | N,N-Diethyl-N'-(6-methoxy-4-methyl-quinolin-8-yl)-hexane-1,6-diamine tosylate |
| SMILES | C1(OC)C=C2C(C)=CC=NC2=C(NCCCCCCN(CC)CC)C=1.C1(C=CC(C)=CC=1)S(=O)(=O)O |
| MFCD | MFCD17392572 |
| InChi | InChI=1S/C21H33N3O.C7H8O3S/c1-5-24(6-2)14-10-8-7-9-12-22-20-16-18(25-4)15-19-17(3)11-13-23-21(19)20;1-6-2-4-7(5-3-6)11(8,9)10/h11,13,15-16,22H,5-10,12,14H2,1-4H3;2-5H,1H3,(H,8,9,10) |
| InChiKey | LOBPWLFCZDGYKW-UHFFFAOYSA-N |
| CID | 24769161 |
| Short Description | Succinate dehydrogenase inhibitor |
References
- A.M. Dueñas-Romero et al. Interaction of sitamaquine with membrane lipids of Leishmania donovani promastigotes. Biochim. Biophys. Acta. 2007, 1768, 246-252.
- C. López-Martín et al. Sitamaquine sensitivity in Leishmania species is not mediated by drug accumulation in acidocalcisomes. Antimicrob. Agents Chemother. 2008, 52, 4030-4036.
- L. Carvalho et al. The 8-aminoquinoline analogue sitamaquine causes oxidative stress in Leishmania donovani promastigotes by targeting succinate dehydrogenase. Antimicrob. Agents Chemother. 2011, 55, 4204-4210.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1267 | MNITMT |
From $82.50 |
| 1970 | Laquinimod |
From $77.00 |
| 2377 | Vidofludimus |
From $137.50 |
| 2476 | DEAB |
From $55.00 |
| 2551 | Alda 1 |
From $71.50 |
Other Categories
Get a Quote for
Loading...