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Antalarmin hydrochloride
Axon 1321
- Parent CAS: 157284-96-3
Purity:
99%
- Soluble in DMSO
- MF: C24H34N4.HCl
- MW: 415.01
Description
Non-peptide CRF1 corticotropin-releasing factor receptor antagonist
More Information
| Parent CAS No. | 157284-96-3 |
|---|---|
| Chemical Name | Butyl-ethyl-[2,5,6-trimethyl-7-(2,4,6-trimethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-amine hydrochloride |
| SMILES | C1(C)C(N2C3N=C(C)N=C(N(CC)CCCC)C=3C(C)=C2C)=C(C)C=C(C)C=1.Cl |
| MFCD | MFCD05664721 |
| InChi | InChI=1S/C24H34N4.ClH/c1-9-11-12-27(10-2)23-21-18(6)19(7)28(24(21)26-20(8)25-23)22-16(4)13-15(3)14-17(22)5;/h13-14H,9-12H2,1-8H3;1H |
| InChiKey | CGDGXEDXEXACKQ-UHFFFAOYSA-N |
| CID | 16078945 |
| Short Description | CRF-1 antagonist |
References
- EL Webster et al. In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation. Endocrinology, 1996, 137, 5747-5750.
- EM Jutkiewicz et al. The effects of CRF antagonists, antalarmin, CP154,526, LWH234, and R121919, in the forced swim test and on swim-induced increases in adrenocorticotropin in rats. Psychopharmacology (Berl). 2005, 180(2), 215-223.
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