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BX 912
- Soluble in 0.1N HCl(aq), DMSO and EtOH
- MF: C20H23BrN8O
- MW: 471.35
Description
BX 912 is an inhibitor of 3-phosphoinositide-dependent kinase-1 (PDPK1/PDK1). It is used as a tool compound to study PDPK1-mediated signaling and downstream regulation of AGC kinase pathways.
PDPK1 plays an important role in growth factor signaling and PI3K pathway biology. BX 912 is useful for research on kinase-dependent signal transduction, cellular proliferation, and pathway modulation in disease-relevant models.
Key Features
- PDPK1/PDK1 inhibitor
- Targets 3-phosphoinositide-dependent kinase-1
- Useful for PI3K-related pathway studies
- Supports research on growth factor signaling
Applications
- PDPK1 and AGC kinase pathway research
- PI3K-dependent signaling studies
- Growth factor signaling research
- Kinase inhibition studies
- Cell signaling and disease model research
More Information
| Parent CAS No. | 702674-56-4 |
|---|---|
| Chemical Name | Pyrrolidine-1-carboxylic acid (3-{5-bromo-4-[2-(1H-imidazol-4-yl)-ethylamino]-pyrimidin-2-ylamino}-phenyl)-amide |
| SMILES | C1(Br)C=NC(NC2C=CC=C(NC(=O)N3CCCC3)C=2)=NC=1NCCC1N=CNC=1 |
| MFCD | MFCD10565925 |
| InChi | InChI=1S/C20H23BrN8O/c21-17-12-24-19(28-18(17)23-7-6-16-11-22-13-25-16)26-14-4-3-5-15(10-14)27-20(30)29-8-1-2-9-29/h3-5,10-13H,1-2,6-9H2,(H,22,25)(H,27,30)(H2,23,24,26,28) |
| InChiKey | DMMILYKXNCVKOJ-UHFFFAOYSA-N |
| CID | 11754511 |
| Short Description | PDK1 inhibitor |
References
- RI Feldman et al. Novel Small Molecule Inhibitors of 3-Phosphoinositide-dependent Kinase-1. J. Biol. Chem., 2005, 280(20), 19867-19874.
- C Peifer and DR Alessi. Small-Molecule Inhibitors of PDK1. ChemMedChem. 2008, 3 (10), 1810. Review.
- List of publications utilizing BX 912 (Axon 1130) purchased from Axon Medchem
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