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Alosetron hydrochloride
- Parent CAS: 122852-42-0
- Soluble in water and DMSO
- MF: C17H18N4O.HCl
- MW: 330.81
Description
Alosetron hydrochloride is a potent and selective 5-HT3 receptor antagonist. It is a clinically used serotonin receptor antagonist and a useful reference compound for studies of 5-HT3-mediated gastrointestinal and sensory signaling.
5-HT3 receptors are cation channels expressed in peripheral and central neurons and are important in emesis and visceral sensation. Alosetron hydrochloride is relevant for IBS-related pathway research and 5-HT3 antagonist pharmacology.
Key Features
- Potent and selective 5-HT3 receptor antagonist
- Clinically used reference antagonist
- Relevant to gastrointestinal serotonin signaling
- Blocks serotonin 5-HT3 receptor ion-channel activity
Applications
- 5-HT3 receptor pharmacology
- Irritable bowel syndrome pathway research
- Visceral sensory signaling studies
- Serotonergic ion channel antagonist assays
More Information
| Parent CAS No. | 122852-42-0 |
|---|---|
| Chemical Name | 5-Methyl-2-(5-methyl-3H-imidazol-4-ylmethyl)-2,3,4,5-tetrahydro-pyrido[4,3-b]indol-1-one hydrochloride |
| SMILES | C1=CC2C3C(=O)N(CC4=C(C)N=CN4)CCC=3N(C)C=2C=C1.Cl |
| MFCD | MFCD00865546 |
| InChi | InChI=1S/C17H18N4O.ClH/c1-11-13(19-10-18-11)9-21-8-7-15-16(17(21)22)12-5-3-4-6-14(12)20(15)2;/h3-6,10H,7-9H2,1-2H3,(H,18,19);1H |
| InChiKey | FNYQZOVOVDSGJH-UHFFFAOYSA-N |
| CID | 2099 |
| Short Description | 5-HT3 antagonist |
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