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APS-2-79
Axon 2611
- Parent CAS: 2002381-25-9
Purity:
98%
- Soluble in DMSO
- MF: C23H21N3O3.HCl
- MW: 423.89
Description
Small molecule that stabilizes the KSR (Kinase suppressor of Ras) inactive state and antagonizes oncogenic Ras signalling (IC50 value 120 nM against ATP-biotin probe-labelling of KSR2). Furthermore, APS-2-79 modulates KSR-dependent MAPK signaling, and increases the potency of several MEK inhibitors, specifically within Ras-mutant cell lines by antagonizing release of negative feedback signaling.
More Information
| Parent CAS No. | 2002381-25-9 |
|---|---|
| Chemical Name | 6,7-dimethoxy-N-(2-methyl-4-phenoxyphenyl)quinazolin-4-amine hydrochloride |
| SMILES | N1=C2C(C=C(OC)C(OC)=C2)=C(NC2=CC=C(OC3=CC=CC=C3)C=C2C)N=C1.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C23H21N3O3.ClH/c1-15-11-17(29-16-7-5-4-6-8-16)9-10-19(15)26-23-18-12-21(27-2)22(28-3)13-20(18)24-14-25-23;/h4-14H,1-3H3,(H,24,25,26);1H |
| InChiKey | LIXKSHWZJNNZHG-UHFFFAOYSA-N |
| CID | 122177134 |
| Short Description | KSR/Ras inhibitor |
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