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CPI-613
- Devimistat - 6,8-Bis(benzylthio)octanoic acid
Axon 2125
CAS:
95809-78-2
Purity:
100%
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C22H28O2S2
- MW: 388.59
Description
A small molecular inhibitor of a mitochondrial enzyme pyruvate dehydrogenase (PDH) complex; 6,8-bis(benzylthio)octanoic acid selectively attacks the regulatory aspects of tumor cell mitochondrial metabolism, activating both apoptotic (programmed cell death) and non-apoptotic (necrosis-like) cell death pathways.
More Information
| Parent CAS No. | 95809-78-2 |
|---|---|
| Chemical Name | 6,8-Bis(benzylthio)octanoic acid |
| SMILES | C(O)(=O)CCCCC(SCC1=CC=CC=C1)CCSCC1=CC=CC=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C22H28O2S2/c23-22(24)14-8-7-13-21(26-18-20-11-5-2-6-12-20)15-16-25-17-19-9-3-1-4-10-19/h1-6,9-12,21H,7-8,13-18H2,(H,23,24) |
| InChiKey | ZYRLHJIMTROTBO-UHFFFAOYSA-N |
| CID | 24770514 |
| Short Description | PDH inhibitor |
References
- Z Zachar et al. Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo. J. Mol. Med. (Berl). 2011, 89(11), 1137-1148.
- KC Lee et al. Formation and anti-tumor activity of uncommon in vitro and in vivo metabolites of CPI-613, a novel anti-tumor compound that selectively alters tumor energy metabolism. Drug Metab. Lett. 2011, 5(3), 163-182.
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