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KRP203
- Mocravimod
- Parent CAS: 509092-16-4
- Soluble in DMSO
- MF: C24H26ClNO3S.HCl
- MW: 480.45
Description
Selective sphingosine-1-phosphate (S1P) receptor 1 agonist; immunosuppressant.
More Information
| Parent CAS No. | 509092-16-4 |
|---|---|
| Chemical Name | 2-amino-2-(4-(3-(benzyloxy)phenylthio)-2-chlorophenethyl)propane-1,3-diol hydrochloride |
| SMILES | C(C1C=CC(SC2C=CC=C(OCC3C=CC=CC=3)C=2)=CC=1Cl)CC(N)(CO)CO.Cl |
| MFCD | MFCD09952233 |
| InChi | InChI=1S/C24H26ClNO3S.ClH/c25-23-14-22(10-9-19(23)11-12-24(26,16-27)17-28)30-21-8-4-7-20(13-21)29-15-18-5-2-1-3-6-18;/h1-10,13-14,27-28H,11-12,15-17,26H2;1H |
| InChiKey | MYIFLDFUXIHOCJ-UHFFFAOYSA-N |
| CID | 11155873 |
| Short Description | S1PR1 inhibitor |
References
- M Takahashi et al. A novel immunomodulator KRP-203 combined with cyclosporine prolonged graft survival and abrogated transplant vasculopathy in rat heart allografts. Transplantation Proceedings 2005, 37(1), 143-145.
- T Kaneko etal. Sphingosine-1-phosphate receptor agonists suppress concanavalin A-induced hepatic injury in mice. Biochem. Biophys. Res. Commu. 2006, 345(1), 85-92.
- J Song et al. A novel sphingosine 1-phosphate receptor agonist, 2-amino-2-propanediol hydrochloride (KRP-203), regulates chronic colitis in interleukin-10 gene-deficient mice. J. Pharmacol. Exp. Ther. 2008, 324(1), 276-283.
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