Varespladib methyl
- A-002 - LY3333013 - S-3013
Axon 4032
CAS:
172733-08-3
Purity:
99%
- Soluble in DMSO
- MF: C22H22N2O5
- MW: 394.42
Description
Varespladib methyl is a secretory phospholipase A2 (sPLA2) inhibitor. It is an orally bioavailable prodrug of the varespladib.
More Information
| Parent CAS No. | 172733-08-3 |
|---|---|
| Chemical Name | Methyl 2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-1H-indol-4-yloxy)acetate |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1C(OCC(OC)=O)=C2C(C(=O)C(N)=O)=C(CC)N(CC3C=CC=CC=3)C2=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C22H22N2O5/c1-3-15-20(21(26)22(23)27)19-16(24(15)12-14-8-5-4-6-9-14)10-7-11-17(19)29-13-18(25)28-2/h4-11H,3,12-13H2,1-2H3,(H2,23,27) |
| InChiKey | VJYDOJXJUCJUHL-UHFFFAOYSA-N |
| CID | 9886917 |
| Short Description | sPLA2 inhibitor |
References
- JD Bradley et al. A randomized, double-blinded, placebo-controlled clinical trial of LY333013, a selective inhibitor of group II secretory phospholipase A2, in the treatment of rheumatoid arthritis. J Rheumatol. 2005 Mar;32(3):417-23.
- M Lewin et al. Varespladib (LY315920) Appears to Be a Potent, Broad-Spectrum, Inhibitor of Snake Venom Phospholipase A2 and a Possible Pre-Referral Treatment for Envenomation. Toxins (Basel). 2016 Aug 25;8(9):248.
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