Varespladib
- LY315920
Axon 4077
CAS:
172732-68-2
Purity:
99%
- Soluble in DMSO
- MF: C21H20N2O5
- MW: 380.39
Description
Varespladib is an inhibitor of human and mouse sPLA2 group IIA, V, and X enzymes with IC50 values in the low nM range.
More Information
| Parent CAS No. | 172732-68-2 |
|---|---|
| Chemical Name | 2-(3-(2-Amino-2-oxoacetyl)-1-benzyl-2-ethyl-1H-indol-4-yloxy)acetic acid |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1C(OCC(O)=O)=C2C(C(=O)C(=O)N)=C(CC)N(CC3C=CC=CC=3)C2=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C21H20N2O5/c1-2-14-19(20(26)21(22)27)18-15(9-6-10-16(18)28-12-17(24)25)23(14)11-13-7-4-3-5-8-13/h3-10H,2,11-12H2,1H3,(H2,22,27)(H,24,25) |
| InChiKey | BHLXTPHDSZUFHR-UHFFFAOYSA-N |
| CID | 155815 |
| Short Description | sPLA2 inhibitor |
References
- DW Snyder et al. Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti-inflammatory drugs, SPI. J Pharmacol Exp Ther. 1999 Mar;288(3):1117-24.
- H Fraser et al. Varespladib (A-002), a secretory phospholipase A2 inhibitor, reduces atherosclerosis and aneurysm formation in ApoE-/- mice. J Cardiovasc Pharmacol. 2009 Jan;53(1):60-5.
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