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QND7
- Soluble in DMSO
- MF: C21H22N4
- MW: 330.43
Description
QND7 is a α7-nicotinic acetylcholine receptor antagonist (Ka value of 6.7 μM). QND7 suppresses non-small cell lung cancer cell proliferation and migration via inhibition of Akt/mTOR signaling.
More Information
| Parent CAS No. | 1779540-13-4 |
|---|---|
| Chemical Name | 3-(4-(Biphenyl-4-yl)-1H-1,2,3-triazol-1-yl)quinuclidine |
| SMILES | C1(CN2CCC1CC2)N1N=NC(C2C=CC(C3C=CC=CC=3)=CC=2)=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C21H22N4/c1-2-4-16(5-3-1)17-6-8-18(9-7-17)20-14-25(23-22-20)21-15-24-12-10-19(21)11-13-24/h1-9,14,19,21H,10-13,15H2 |
| InChiKey | FCPFSJPNOQBLFM-UHFFFAOYSA-N |
| CID | 122573079 |
| Short Description | nAChR antagonist |
References
- W Witayateeraporn et al. α7-Nicotinic acetylcholine receptor antagonist QND7 suppresses non-small cell lung cancer cell proliferation and migration via inhibition of Akt/mTOR signaling. Biochem Biophys Res Commun. 2020 Jan 22;521(4):977-983.
- K Arunrungvichian et al. Selectivity optimization of substituted 1,2,3-triazoles as α7 nicotinic acetylcholine receptor agonists. ACS Chem Neurosci. 2015;6(8):1317-1330.
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