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GSK481
- GSK'481
Axon 2608
CAS:
1622849-58-4
Purity:
98%
- Soluble in DMSO
- MF: C21H19N3O4
- MW: 377.39
Description
Potent inhibitor of Receptor-interacting serine/threonine-protein kinase 1 (RIPK1 or RIP1; IC50 value 2.8 nM for inhibition of S166 phosphorylation of hWT RIP1) exhibiting a remarkable specificity over >450 other kinases. GSK'481 protects against TNF-induced inflammation and lethal shock.
More Information
| Parent CAS No. | 1622849-58-4 |
|---|---|
| Chemical Name | (S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)isoxazole-3-carboxamide |
| MFCD | N.A. |
| Short Description | RIP1 kinase inhibitor |
References
- PA Harris et al. DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors. J Med Chem. 2016 Mar 10;59(5):2163-78.
- P Geserick et al. Absence of RIPK3 predicts necroptosis resistance in malignant melanoma. Cell Death Dis. 2015 Sep 10;6:e1884.
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